DNA repair discovery could lead to drugs to reverse ageing

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A drug to reverse ageing and treat cancer may be a step closer after a team of scientists identified a critical step in how cells repair damaged DNA.

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Key points:

  • Researchers say mice given a vitamin booster were better at repairing DNA damage
  • “Many aspects of ageing were reversed”
  • The discovery could lead to drugs to treat cancer and Alzheimer’s, and improve astronauts’ health

Their discovery could even help survivors of childhood cancers and help NASA get astronauts to Mars.

“For most of the 20th century we knew that our [cells’ ability to repair DNA gets worse over time] and we get old and it’s the main reason we get cancer,” Harvard and UNSW professor David Sinclair said.

“So what we’ve discovered is the reason why.”

Published in the journal Science, the international team identified how a vitamin called NAD+ was regulating the interactions that control DNA repair.

The scientists said experiments showed that when mice were given an NAD+ booster called NMN, their cells were better at repairing DNA damage caused by radiation exposure and ageing.

“We took old mice that were 20 months old which is [equivalent to] a 60-70-year-old human and we gave them NMN and we found that… many aspects of ageing were reversed,” Professor Sinclair said.

“Their DNA repair activities went up to youthful levels and they were more resistant to radiation and should therefore be more protected against cancer and ageing itself.

“Essentially every aspect of their ageing process that we looked at is reversed in about a week so we’re very excited to see if this actually happens in people when we test it in the next couple of months.”

Human trials of NMN therapy will start in Boston in the next six months.

“Then we should be able to go into the next studies which we’re hoping to do in the US and in Australia and then we really get serious,” Professor Sinclair said.

“We start looking at how fast people can walk, how strong they are and then eventually we want to get this molecule on the market as a drug to treat a disease like cancer, Alzheimer’s or diabetes.”

Professor Sinclair and his colleague Dr Lindsay Wu are working on making NMN into a drug substance.

NASA sees potential for Mars mission

NASA — which is investigating a manned Mars mission — is very keen on the research because the gruelling two-year journey would expose its astronauts to significant levels of cosmic radiation.

The University of New South Wales said on a trip to Mars they estimate 5 per cent of the astronauts’ cells would die and would have an almost 100 per cent chance of getting cancer.

“It’s quite a scary thing because cosmic radiation can get into their spaceship and bounce around causing significant DNA damage and so the only solution for that at the moment is to have thicker and thicker lead shielding on the outside of the spacecraft,” Dr Wu said.

“We’ve managed to get a contract through NASA and this therapy hopefully will be on the mission to Mars given those astronauts have to be in space for two years in each direction.”

The discovery could also help survivors of childhood cancers, who can suffer what Dr Wu terms “accelerated ageing”.

“Up until very recently we haven’t really known what the health of childhood cancer survivors was like because quite frankly we didn’t have enough of them surviving it,” he said.

“So the health, the long-term health of these cancer survivors is of great concern… so what this finding is useful for is improving the DNA repair following for example radiation therapy.”

Peter Okafor
Peter Okaforhttp://Naija247news.com
Peter Okafor Financial Journalist | Editor | Contributor Overview: Peter Okafor is a seasoned Financial Journalist, astute Editor, and valued Contributor at Naija247news Media Group. With an unwavering passion for dissecting complex financial landscapes, Peter has become a trusted name in delivering incisive and insightful coverage of economic events, market trends, and corporate dynamics. Professional Journey Peter's journey in financial journalism has been marked by a commitment to excellence. Joining the ranks of Naija247news, he has consistently demonstrated a keen understanding of the intricate interplay between finance and the global socio-economic fabric. Expertise: Specializing in financial markets, economic analyses, and business developments, Peter Okafor has honed his expertise over the years. His ability to unravel intricate financial narratives and present them in a comprehensible manner sets him apart in the world of financial journalism. Contributions As an Editor and Contributor, Peter has played a pivotal role in shaping the narrative of Naija247news. His contributions extend to thought-provoking articles, in-depth market analyses, and coverage of key events that impact the financial landscape. Educational Background: Peter holds a degree in Journalism, complemented by specialized courses in Finance and Business Reporting. His educational foundation has provided him with the tools to navigate the intricate world of financial journalism. Innovation and Adaptability: In an era of evolving media landscapes, Peter Okafor exemplifies innovation and adaptability. Leveraging digital platforms and emerging technologies, he ensures that financial insights reach a diverse audience, fostering financial literacy and awareness. Awards and Recognition: Peter's commitment to journalistic excellence has not gone unnoticed. He has been the recipient of several awards, recognizing his outstanding contributions to the field of financial journalism. Vision for the Future: Looking ahead, Peter Okafor envisions a future where financial journalism continues to empower individuals, shape economic policies, and drive positive change. His dedication to staying at the forefront of financial news underscores his commitment to this vision. Connect with Peter Okafor: - LinkedIn: [Peter Okafor](#) - Twitter: [@PeterOkafor_N247](#) In the dynamic realm of financial journalism, Peter Okafor stands as a stalwart, combining experience, expertise, and a forward-looking vision to illuminate the path of financial understanding for a global audience.

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